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Irvine, California — Vitreoretinal Technologies (VRT) recently closed on an $8.8 million Series A financing with lead
investor De Novo Ventures and a group of private investors.
Vitreoretinal Technologies (VRT) is a specialty pharmaceutical company with specific focus on
ophthalmology. The company’s drug candidates are focused on diabetic retinopathy, glaucoma
and retinitis pigmentosa.
"All of us at De Novo Ventures are delighted to have the opportunity to invest in Vitreor etinal
Technologies. The market potential for the three products which will soon be administered to
patients in phase III trials is enormous. The positive results from previous trials are suggestive of
significant clinical benefit in diabetic retinopathy, retinitis pigmentosa, and glaucoma," said new
board member Fred Dotzler.
”We believe our core strengths are a combination of unique drug development processes and a
deep knowledge of the ophthalmic market,” said Hampar Karageozian, a founder and the CEO of
VRT. “The recent success of AMD drugs, such as Lucentis, has drawn significant attention from
large Pharma and the Investment community. This trend and our pipeline should place us in a
favorable position.”
Ramgopal Rao, VRT’s Chief Operating Officer said, “With this funding in place VRT is in a n excellent
position to commence the planned Phase lll clinical studies and look forward to future
regulatory approvals. We value participation of De Novo Ventures, a first tier venture firm with
vast experience with early and mid-stage life science companies, in our growth and corporate
development.”
Co-founder and Chief Medical Officer, Vicken Karageozian, MD said “I look forward to an
effective treatment option for diabetic retinopathy patients. With rapidly growing rates of
diabetes world-wide, Vitreosolve® ha s the potentia l to be one of the most importan t drug s in
ophthalmology.”
It is estimated that there are 8 million diabetic retinopathy patients in the US. There is no effective
treatment available for arresting or reversing the disease process today. We estimate the total
US market potential to be several billions of dollars. Similarly, glaucoma represents a multibillion
dollar market with close to 2 million patients in the US. VRT drugs address these unmet
market needs.
VRT has two drug candidates; Vitreosolve® for diabetic retinopathy and Neurosolve® for
glaucoma and retinitis pigmentosa. Both drugs are small molecules with a long history of
safety for systemic use in humans and were optimized for safety and efficacy through a series of
Phase ll trials in humans. Several other applications for this family of compounds are in development.
Vitreosolve® for diabetic retinopathy is the company' s lead candidate and it has been approved
for Phase lll clinical trials by the FDA. VRT is currently recruiting sites in the US and overseas and
projects that the first patient will be injected within the next 60 days. Neurosolve® for glaucoma also received a phase lll designation from the FDA, and VRT plans to start a Phase III study in June
2008. In addition, Neurosolve® has also been granted an orphan status by the US FDA for retinitis pigmentosa indication.
Contacts
Vitreoretinal Technologies, Inc.
Ramgopal Rao
Chief Operating Officer
(949) 753-1008 Office
(714) 299-9986 Mobile
De Novo Ventures
Frederick Dotzler
Managing Director
De Novo Venture Partners
(650) 329-1999
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